InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mien1

Summary

InnateDB Protein

IDBP-210621.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mien1

Protein Name

RIKEN cDNA 1810046J19 gene

Synonyms

1810046J19Rik; AI463380; Rdx12;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002655

InnateDB Gene

IDBG-210619 (Mien1)

Protein Structure

UniProt Annotation

Function

Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:17503775}. Cell membrane {ECO:0000250}; Lipid- anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in kidney followed by brain and testis. {ECO:0000269PubMed:17503775}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008430	selenium binding

Biological Process

GO:0006915	apoptotic process
GO:0030335	positive regulation of cell migration
GO:0043066	negative regulation of apoptotic process
GO:0045454	cell redox homeostasis
GO:0051491	positive regulation of filopodium assembly