Version 5.4
Mus musculus Protein: Trpc4ap
Summary
InnateDB Protein IDBP-210651.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trpc4ap
Protein Name transient receptor potential cation channel, subfamily C, member 4 associated protein
Synonyms 4833429F06Rik; D2Ertd113e; mFLJ00177; Trrp4ap; truss;
Species Mus musculus
Ensembl Protein ENSMUSP00000037574
InnateDB Gene IDBG-210649 (Trpc4ap)
Protein Structure
UniProt Annotation
Function Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC (By similarity). Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1. {ECO:0000250, ECO:0000269PubMed:16876162, ECO:0000269PubMed:20458742}.
Subcellular Localization
Disease Associations
Tissue Specificity Widely expressed, with high levels in heart, liver and testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019902 phosphatase binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
Cellular Component
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
Protein Structure and Domains
PDB ID MGI:1930751
InterPro IPR022162 Protein of unknown function DUF3689
PFAM PF12463
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JLV2
PhosphoSite PhosphoSite-Q9JLV2
TrEMBL Q571F0
UniProt Splice Variant
Entrez Gene 56407
UniGene Mm.268304
RefSeq NP_001156924
MGI ID
MGI Symbol Trpc4ap
OMIM
CCDS CCDS50769
HPRD
IMGT
EMBL AF093589 AF130458 AF509881 AK156047 AK165259 AK170085 AK171404 AK220239 BC003931 BC033274 BC057330 CH466551
GenPept AAF36513 AAH03931 AAH33274 AAH57330 AAL08422 AAM46938 BAD90164 BAE33561 BAE38109 BAE41555 BAE42434 EDL06138

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca