InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBA6

Summary

InnateDB Protein

IDBP-21068.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBA6

Protein Name

ubiquitin-like modifier activating enzyme 6

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000313454

InnateDB Gene

IDBG-21066 (UBA6)

Protein Structure

UniProt Annotation

Function

Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility. {ECO:0000269PubMed:15202508, ECO:0000269PubMed:17597759, ECO:0000269PubMed:17889673}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed. Isoform 2 is predominantly expressed in testis with higher expression in adult testis than in fetal testis. {ECO:0000269PubMed:15202508, ECO:0000269PubMed:17597759}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.

Experimentally validated
Total	44 [view]
Protein-Protein	44 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008641	small protein activating enzyme activity
GO:0016874	ligase activity
GO:0019780	FAT10 activating enzyme activity

Biological Process

GO:0006464	cellular protein modification process
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016567	protein ubiquitination

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000011 Ubiquitin/SUMO-activating enzyme E1
IPR000127 Ubiquitin-activating enzyme repeat
IPR000594 UBA/THIF-type NAD/FAD binding fold
IPR009036 Molybdenum cofactor biosynthesis, MoeB
IPR018075 Ubiquitin-activating enzyme, E1
IPR018965 Ubiquitin-activating enzyme e1, C-terminal
IPR019572 Ubiquitin-activating enzyme

PFAM

PF02134
PF00899
PF09358
PF10585

PRINTS

PR01849

PIRSF

SMART

SM00985

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt