InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eif6

Summary

InnateDB Protein

IDBP-210710.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif6

Protein Name

eukaryotic translation initiation factor 6

Synonyms

1110004P11; AA408895; CAB; eIF-6; imc-415; Itgb4bp; p27(BBP); p27BBP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029142

InnateDB Gene

IDBG-210708 (Eif6)

Protein Structure

UniProt Annotation

Function

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity. {ECO:0000255HAMAP-Rule:MF_03132}.

Subcellular Localization

Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus.

Disease Associations

Tissue Specificity

Detected in bladder, duodenum, liver, esophagus, pancreas and testis with lower levels in muscle (at protein level). {ECO:0000269PubMed:11290417}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 138 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	138 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0005515	protein binding
GO:0043022	ribosome binding
GO:0043023	ribosomal large subunit binding

Biological Process

GO:0000054	ribosomal subunit export from nucleus
GO:0006413	translational initiation
GO:0042256	mature ribosome assembly
GO:0042273	ribosomal large subunit biogenesis

Cellular Component

GO:0005634	nucleus
GO:0005638	lamin filament
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005882	intermediate filament
GO:0070062	extracellular vesicular exosome