InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gsdma

Summary

InnateDB Protein

IDBP-210713.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gsdma

Protein Name

gasdermin A

Synonyms

BB149167; Gsdm; Gsdm1; Gsdma1; H312E;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000017348

InnateDB Gene

IDBG-210711 (Gsdma)

Protein Structure

UniProt Annotation

Function

Induces apoptosis. {ECO:0000250}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000269PubMed:10967128}.

Disease Associations

Tissue Specificity

Expressed predominantly in the gastrointestinal (GI) tract and in the skin at a lower level. In the GI tract, the expression is highly restricted to the esophagus and forestomach. {ECO:0000269PubMed:10967128, ECO:0000269PubMed:17350798}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0006915

apoptotic process

Cellular Component

GO:0005737	cytoplasm
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1889509

InterPro

IPR007677 Gasdermin

PFAM

PF04598

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9EST1

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

57911

UniGene

Mm.458085

RefSeq

NP_067322

MGI ID

MGI Symbol

Gsdma

OMIM

CCDS

CCDS25358

HPRD

IMGT

EMBL

AB033595 AK028645 AK028698 AK029062 AL590963

GenPept

BAB13697 BAC26045 BAC26073 BAC26272 CAM46199