Version 5.4
Mus musculus Protein: Msl1
Summary
InnateDB Protein IDBP-210771.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Msl1
Protein Name male-specific lethal 1 homolog (Drosophila)
Synonyms 2810017F12Rik; 4121402D02Rik; 4930463F05Rik; AA682082; Msl-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000042792
InnateDB Gene IDBG-210769 (Msl1)
Protein Structure
UniProt Annotation
Function Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-17' which is implicated in the formation of higher-order chromatin. structure (By similarity). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-5' (H3K4me) and 'Lys-80' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation. {ECO:0000250, ECO:0000269PubMed:21217699}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16119455}.
Disease Associations
Tissue Specificity Expressed in testis and several other tissues. {ECO:0000269PubMed:16119455}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0043984 histone H4-K16 acetylation
Cellular Component
GO:0005634 nucleus
GO:0072487 MSL complex
Protein Structure and Domains
PDB ID MGI:1921276
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PDM1
PhosphoSite PhosphoSite-Q6PDM1
TrEMBL
UniProt Splice Variant
Entrez Gene 74026
UniGene Mm.409986
RefSeq NP_082998
MGI ID 2Y0N
MGI Symbol Msl1
OMIM
CCDS CCDS25364
HPRD
IMGT
EMBL AK014463 AK015496 AK053719 AK161412 AL590963 BC043039 BC055715 BC058629 DQ387855
GenPept AAH43039 AAH55715 AAH58629 ABD46887 BAB29369 BAB29868 BAC35489 BAE36380 CAM46183 CAM46184 CAM46185 CAM46186

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca