InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ate1

Summary

InnateDB Protein

IDBP-210783.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ate1

Protein Name

arginyltransferase 1

Synonyms

AI225793; AW547406;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033139

InnateDB Gene

IDBG-210781 (Ate1)

Protein Structure

UniProt Annotation

Function

Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues. {ECO:0000269PubMed:9858543}.

Subcellular Localization

Isoform ATE1-1: Nucleus. Cytoplasm.Isoform ATE1-2: Cytoplasm.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:9858543}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004057	arginyltransferase activity
GO:0005515	protein binding

Biological Process

GO:0016598

protein arginylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1333870

InterPro

IPR007471 Arginine-tRNA-protein transferase, N-terminal
IPR007472 Arginine-tRNA-protein transferase, C-terminal
IPR016181 Acyl-CoA N-acyltransferase
IPR017137 Arginine-tRNA-protein transferase 1, eukaryotic

PFAM

PF04376
PF04377

PRINTS

PIRSF

PIRSF037207

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z2A5