Version 5.4
Mus musculus Protein: Wipf2
Summary
InnateDB Protein IDBP-210814.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wipf2
Protein Name WAS/WASL interacting protein family, member 2
Synonyms 1110014J05Rik; 5730509C05Rik; AA407487; Gm1176; Wich; Wire;
Species Mus musculus
Ensembl Protein ENSMUSP00000046991
InnateDB Gene IDBG-210812 (Wipf2)
Protein Structure
UniProt Annotation
Function Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized to stress fibers and bundles of actin filaments. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID MGI:1924462
InterPro IPR003124 WH2 domain
PFAM PF02205
PRINTS
PIRSF
SMART SM00246
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PEV3
PhosphoSite PhosphoSite-Q6PEV3
TrEMBL D3Z0K7
UniProt Splice Variant
Entrez Gene 68524
UniGene Mm.473466
RefSeq NP_922922
MGI ID
MGI Symbol Wipf2
OMIM
CCDS CCDS25366
HPRD
IMGT
EMBL AL591067 BC057854
GenPept AAH57854

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca