InnateDB Protein
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IDBP-210838.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Romo1
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Protein Name
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reactive oxygen species modulator 1
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Synonyms
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2010100O12Rik; AI853864;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000085981
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InnateDB Gene
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IDBG-210836 (Romo1)
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Protein Structure
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Function |
Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage (By similarity). {ECO:0000250}.Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Mitochondrion inner membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Detected in brain, liver and kidney. {ECO:0000269PubMed:16842742}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
GO:0001302
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replicative cell aging
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GO:0008284
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positive regulation of cell proliferation
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GO:0034614
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cellular response to reactive oxygen species
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GO:0042742
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defense response to bacterium
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GO:2000379
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positive regulation of reactive oxygen species metabolic process
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Cellular Component |
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PDB ID |
MGI:1914317
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InterPro |
IPR018450
Reactive oxygen species modulator 1
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PFAM |
PF10247
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P60603
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
67067
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UniGene |
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RefSeq |
NP_001157689
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MGI ID |
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MGI Symbol |
Romo1
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OMIM |
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CCDS |
CCDS38296
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HPRD |
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IMGT |
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EMBL |
AK003488
AK008300
AY028425
BC028749
BX649640
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GenPept |
AAH28749
AAK18748
BAB22816
BAB25585
CAM13495
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