Version 5.4
Mus musculus Protein: Krt27
Summary
InnateDB Protein IDBP-210996.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Krt27
Protein Name keratin 27
Synonyms Krt1-c29; mIRSa3.1;
Species Mus musculus
Ensembl Protein ENSMUSP00000017732
InnateDB Gene IDBG-210994 (Krt27)
Protein Structure
UniProt Annotation
Function Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs). {ECO:0000269PubMed:14996088, ECO:0000269PubMed:17920809}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:14996088}.
Disease Associations
Tissue Specificity Expressed in skin. Expressed in the Henle layer and cuticle of the irs in hair follicle bulb. In the hair follicle, expression was observed in all layers of the irs but was stronger in the Henle layer and cuticle than the Huxley layer until the Henle layer differentiated (at protein level). {ECO:0000269PubMed:10087197, ECO:0000269PubMed:14996088}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
Biological Process
GO:0031069 hair follicle morphogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005882 intermediate filament
Protein Structure and Domains
PDB ID MGI:1339999
InterPro IPR001664 Intermediate filament protein
IPR002957 Keratin, type I
IPR009053 Prefoldin
PFAM PF00038
PRINTS PR01248
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z320
PhosphoSite PhosphoSite-Q9Z320
TrEMBL
UniProt Splice Variant
Entrez Gene 16675
UniGene Mm.440476
RefSeq NP_034796
MGI ID
MGI Symbol Krt27
OMIM
CCDS CCDS25379
HPRD
IMGT
EMBL AB013607 AL590991
GenPept BAA34228 CAM18787

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca