InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tgif2

Summary

InnateDB Protein

IDBP-211001.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tgif2

Protein Name

TGFB-induced factor homeobox 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000096745

InnateDB Gene

IDBG-210997 (Tgif2)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}. Note=Excluded from nucleoli. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0010470	regulation of gastrulation
GO:0038092	nodal signaling pathway
GO:0045666	positive regulation of neuron differentiation
GO:0060041	retina development in camera-type eye