Mus musculus Protein: Hmx3
Summary
InnateDB Protein IDBP-211004.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hmx3
Protein Name H6 homeobox 3
Synonyms Nkx-5.1; Nkx5-1; Nkx5.1;
Species Mus musculus
Ensembl Protein ENSMUSP00000039018
InnateDB Gene IDBG-211002 (Hmx3)
Protein Structure
UniProt Annotation
Function Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS. {ECO:0000269PubMed:15363417, ECO:0000269PubMed:9389661, ECO:0000269PubMed:9435283}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in the developing CNS, including a specific expression in vestibular structures throughout inner ear development. {ECO:0000269PubMed:11748138, ECO:0000269PubMed:9389661, ECO:0000269PubMed:9435283}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007420 brain development
GO:0007566 embryo implantation
GO:0030154 cell differentiation
GO:0042472 inner ear morphogenesis
GO:0050885 neuromuscular process controlling balance
GO:0060135 maternal process involved in female pregnancy
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:107160
InterPro IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa
PFAM PF00046
PRINTS PR00024
PIRSF
SMART SM00389
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P42581
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 15373
UniGene Mm.323562
RefSeq NP_032283
MGI ID
MGI Symbol Hmx3
OMIM
CCDS CCDS21917
HPRD
IMGT
EMBL AJ009935 BC139482 BC139483 CH466531 X75330
GenPept AAI39483 AAI39484 CAA08911 CAA53079 EDL17717