InnateDB Protein
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IDBP-211004.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Hmx3
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Protein Name
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H6 homeobox 3
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Synonyms
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Nkx-5.1; Nkx5-1; Nkx5.1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000039018
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InnateDB Gene
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IDBG-211002 (Hmx3)
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Protein Structure
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Function |
Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS. {ECO:0000269PubMed:15363417, ECO:0000269PubMed:9389661, ECO:0000269PubMed:9435283}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in the developing CNS, including a specific expression in vestibular structures throughout inner ear development. {ECO:0000269PubMed:11748138, ECO:0000269PubMed:9389661, ECO:0000269PubMed:9435283}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:107160
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InterPro |
IPR001356
Homeobox domain
IPR009057
Homeodomain-like
IPR020479
Homeodomain, metazoa
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PFAM |
PF00046
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PRINTS |
PR00024
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PIRSF |
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SMART |
SM00389
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TIGRFAMs |
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Modification |
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SwissProt |
P42581
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
15373
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UniGene |
Mm.323562
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RefSeq |
NP_032283
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MGI ID |
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MGI Symbol |
Hmx3
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OMIM |
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CCDS |
CCDS21917
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HPRD |
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IMGT |
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EMBL |
AJ009935
BC139482
BC139483
CH466531
X75330
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GenPept |
AAI39483
AAI39484
CAA08911
CAA53079
EDL17717
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