InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hmx3

Summary

InnateDB Protein

IDBP-211004.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hmx3

Protein Name

H6 homeobox 3

Synonyms

Nkx-5.1; Nkx5-1; Nkx5.1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039018

InnateDB Gene

IDBG-211002 (Hmx3)

Protein Structure

UniProt Annotation

Function

Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS. {ECO:0000269PubMed:15363417, ECO:0000269PubMed:9389661, ECO:0000269PubMed:9435283}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in the developing CNS, including a specific expression in vestibular structures throughout inner ear development. {ECO:0000269PubMed:11748138, ECO:0000269PubMed:9389661, ECO:0000269PubMed:9435283}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007420	brain development
GO:0007566	embryo implantation
GO:0030154	cell differentiation
GO:0042472	inner ear morphogenesis
GO:0050885	neuromuscular process controlling balance
GO:0060135	maternal process involved in female pregnancy