InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Krt28

Summary

InnateDB Protein

IDBP-211007.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Krt28

Protein Name

keratin 28

Synonyms

4733401L19Rik; Krt25d;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006963

InnateDB Gene

IDBG-211005 (Krt28)

Protein Structure

UniProt Annotation

Function

Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs). {ECO:0000269PubMed:14996088, ECO:0000269PubMed:17920809}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:14996088}.

Disease Associations

Tissue Specificity

In the hair follicle and bulb, uniformly expressed in all three layers of the inner root sheath (the Henle layer, the Huxley layer and the cuticle) and observed in matrix cells (at protein level). {ECO:0000269PubMed:14996088}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0005737	cytoplasm
GO:0005882	intermediate filament

Protein Structure and Domains

PDB ID

MGI:1918093

InterPro

IPR001664 Intermediate filament protein
IPR002957 Keratin, type I

PFAM

PF00038

PRINTS

PR01248

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A6BLY7

PhosphoSite

PhosphoSite-A6BLY7

TrEMBL

UniProt Splice Variant

Entrez Gene

70843

UniGene

Mm.180256

RefSeq

NP_081850

MGI ID

MGI Symbol

Krt28

OMIM

CCDS

CCDS48906

HPRD

IMGT

EMBL

AB288231 AK014642 AL591165

GenPept

BAB29485 BAF64536 CAM21362