InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nkx1-2

Summary

InnateDB Protein

IDBP-211089.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nkx1-2

Protein Name

NK1 transcription factor related, locus 2 (Drosophila)

Synonyms

Nkx-1.1; Nkx-1.2; Sax1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000052778

InnateDB Gene

IDBG-211087 (Nkx1-2)

Protein Structure

UniProt Annotation

Function

May function in cell specification, particularly in the CNS.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expression detected in adult brain, testis and spleen. In the testis, expressed in the germ cells of the seminiferous epithelium, in elongating spermatids and in spermatozoa. Expressed throughout the brain with highest levels in regions of the cerebral cortex, hippocampus, diencephalon, pons, medulla and cerebellum. In the embryo, expressed in the developing posterior central nervous system. First seen in the ectoderm lateral to the primitive streak, later it encompasses the neural plate. Starting at day 9.5 pc, expressed in distinct areas of spinal cord, hindbrain, midbrain and forebrain. {ECO:0000269PubMed:10681422, ECO:0000269PubMed:7669696}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding