Version 5.4
Mus musculus Protein: Lhpp
Summary
InnateDB Protein IDBP-211104.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lhpp
Protein Name phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Synonyms 2310007H09Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000033241
InnateDB Gene IDBG-211102 (Lhpp)
Protein Structure
UniProt Annotation
Function Phosphatase that hydrolyzes imidodiphosphate, 3- phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004427 inorganic diphosphatase activity
GO:0008969 phosphohistidine phosphatase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0006796 phosphate-containing compound metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1923679
InterPro IPR006355 HAD-superfamily hydrolase, subfamily IIA, hypothetical 2
IPR006357 HAD-superfamily hydrolase, subfamily IIA
IPR023214 HAD-like domain
PFAM PF13344
PF00702
PF08282
PF13419
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D7I5
PhosphoSite PhosphoSite-Q9D7I5
TrEMBL
UniProt Splice Variant
Entrez Gene 76429
UniGene Mm.410293
RefSeq NP_083885
MGI ID
MGI Symbol Lhpp
OMIM
CCDS CCDS21925
HPRD
IMGT
EMBL AK009207 AK140229 BC065789
GenPept AAH65789 BAB26140 BAE24290

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca