Version 5.4
Mus musculus Protein: Fam175b
Summary
InnateDB Protein IDBP-211160.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fam175b
Protein Name family with sequence similarity 175, member B
Synonyms AA589499; Abro1; AI853413; C430003P19Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000081541
InnateDB Gene IDBG-211158 (Fam175b)
Protein Structure
UniProt Annotation
Function Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May act as a central scaffold protein that assembles the various components of the BRISC complex (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031593 polyubiquitin binding
Biological Process
GO:0071497 cellular response to freezing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070552 BRISC complex
Protein Structure and Domains
PDB ID MGI:1926116
InterPro IPR023238 FAM175 family
IPR023239 FAM175 family, BRCA1-A complex, Abraxas subunit
IPR023240 FAM175 family, BRISC complex, Abro1 subunit
PFAM
PRINTS PR02051
PR02052
PR02053
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3TCJ1
PhosphoSite PhosphoSite-Q3TCJ1
TrEMBL Z4YJY0
UniProt Splice Variant
Entrez Gene 109359
UniGene Mm.274824
RefSeq NP_932134
MGI ID
MGI Symbol Fam175b
OMIM
CCDS CCDS21928
HPRD
IMGT
EMBL AC099627 AK170704 AK171524 BC030838
GenPept AAH30838 BAE41965 BAE42506

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca