InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rbl1

Summary

InnateDB Protein

IDBP-211180.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rbl1

Protein Name

retinoblastoma-like 1 (p107)

Synonyms

AW547426; p107; PRB1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029170

InnateDB Gene

IDBG-211178 (Rbl1)

Protein Structure

UniProt Annotation

Function

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor. {ECO:0000269PubMed:15750587}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in fetal heart and liver. Expressed at low levels in all other fetal tissues except skeletal muscle. High levels in neonatal spleen and thymus with low levels in other tissues. In adult, highly expressed in testis. Barely detectable in other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 91 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	91 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007049	cell cycle
GO:0016568	chromatin modification
GO:0043550	regulation of lipid kinase activity
GO:0051726	regulation of cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Protein Structure and Domains

PDB ID

MGI:103300

InterPro

IPR002719 Retinoblastoma-associated protein, B-box
IPR002720 Retinoblastoma-associated protein, A-box
IPR013763 Cyclin-like
IPR015030 Retinoblastoma-associated protein, C-terminal
IPR024599 Retinoblastoma-associated protein, N-terminal

PFAM

PF01857
PF01858
PF08934
PF11934

PRINTS

PIRSF

SMART

SM00385

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q64701