InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zranb1

Summary

InnateDB Protein

IDBP-211183.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zranb1

Protein Name

zinc finger, RAN-binding domain containing 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033265

InnateDB Gene

IDBG-211181 (Zranb1)

Protein Structure

UniProt Annotation

Function

Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'- linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Enriched in punctate localization in the cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0008270	zinc ion binding
GO:0070530	K63-linked polyubiquitin binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0016055	Wnt signaling pathway
GO:0016477	cell migration
GO:0022604	regulation of cell morphogenesis
GO:0030177	positive regulation of Wnt signaling pathway
GO:0035523	protein K29-linked deubiquitination
GO:0070536	protein K63-linked deubiquitination
GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:1990168	protein K33-linked deubiquitination