InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bccip

Summary

InnateDB Protein

IDBP-211255.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bccip

Protein Name

BRCA2 and CDKN1A interacting protein

Synonyms

1110013J05Rik; TOK-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033282

InnateDB Gene

IDBG-211253 (Bccip)

Protein Structure

UniProt Annotation

Function

May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ) (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Note=Colocalizes with BRCA2 in discrete nuclear foci. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019207	kinase regulator activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006281	DNA repair
GO:0007049	cell cycle
GO:0061101	neuroendocrine cell differentiation