Version 5.4
Mus musculus Protein: D7Ertd443e
Summary
InnateDB Protein IDBP-211306.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol D7Ertd443e
Protein Name DNA segment, Chr 7, ERATO Doi 443, expressed
Synonyms 4933400E14Rik; FATS; Gm497;
Species Mus musculus
Ensembl Protein ENSMUSP00000091539
InnateDB Gene IDBG-211304 (D7Ertd443e)
Protein Structure
UniProt Annotation
Function Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. May have a role in the assembly of primary cilia. {ECO:0000269PubMed:20154723, ECO:0000269PubMed:20843368}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Localizes to the actin cytoskeleton in a proportion of cells. Colocalizes with centriolar acetylated tubulin (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in testis. Weak expression found in brain, lung, heart, ovary, thymus, spleen and kidney. {ECO:0000269PubMed:20843368}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0042826 histone deacetylase binding
Biological Process
GO:0006974 cellular response to DNA damage stimulus
GO:0007095 mitotic G2 DNA damage checkpoint
GO:0009411 response to UV
GO:0010212 response to ionizing radiation
GO:0030308 negative regulation of cell growth
GO:0050821 protein stabilization
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0015629 actin cytoskeleton
Protein Structure and Domains
PDB ID MGI:1196431
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt D2J0Y4
PhosphoSite PhosphoSite-D2J0Y4
TrEMBL G3UZQ0
UniProt Splice Variant
Entrez Gene 71007
UniGene Mm.487947
RefSeq NP_001074800
MGI ID
MGI Symbol D7Ertd443e
OMIM
CCDS CCDS57590
HPRD
IMGT
EMBL AC124369 AC126676 CH466531 GQ499374
GenPept ACZ64206 EDL17791

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca