InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptpre

Summary

InnateDB Protein

IDBP-211356.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptpre

Protein Name

protein tyrosine phosphatase, receptor type, E

Synonyms

PTPe; PTPepsilon; RPTPepsilon;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073616

InnateDB Gene

IDBG-211354 (Ptpre)

Protein Structure

UniProt Annotation

Function

Isoform 1 acts as a negative regulator of insulin receptor (IR) signaling and is involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver (By similarity). Plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function. {ECO:0000250}.Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin- induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake.Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Cytoplasm. Note=Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin can induce translocation to the membrane.Isoform 3: Cytoplasm.

Disease Associations

Tissue Specificity

Isoform 2 is expressed in the spleen and thymus (at protein level). Detected in fibroblasts, myeloid cells, macrophages, and T-cells but not in B-cell lines. Isoform 1 and isoform 2 are expressed predominantly in the brain, testes, and lungs, with lower levels present in lymph nodes, thymus, spleen, heart and mammary glands. Isoform 1 is expressed in osteoclasts and not in osteoblasts and its expression is related to osteoclast differentiation. It is also expressed in the erythrocytes. Isoform 2 is strongly expressed in skeletal muscle and L6 skeletal muscle cell line. {ECO:0000269PubMed:18006633, ECO:0000269PubMed:18924107, ECO:0000269PubMed:1932742, ECO:0000269PubMed:8610169, ECO:0000269PubMed:8618876}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0016311	dephosphorylation
GO:0033003	regulation of mast cell activation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0046627	negative regulation of insulin receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0045111	intermediate filament cytoskeleton

Protein Structure and Domains

PDB ID

MGI:97813

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR016336 Receptor tyrosine-protein phosphatase, alpha/epsilon-type
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102

PRINTS

PR00700

PIRSF

PIRSF002006

SMART

SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References