Version 5.4
Mus musculus Protein: Tti1
Summary
InnateDB Protein IDBP-211375.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tti1
Protein Name Tel2 interacting protein 1 homolog (S. pombe)
Synonyms 2610036D13Rik; AI449463;
Species Mus musculus
Ensembl Protein ENSMUSP00000029179
InnateDB Gene IDBG-211373 (Tti1)
Protein Structure
UniProt Annotation
Function Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0032006 regulation of TOR signaling
Cellular Component
GO:0005737 cytoplasm
GO:0031931 TORC1 complex
GO:0031932 TORC2 complex
Protein Structure and Domains
PDB ID MGI:1922675
InterPro IPR016024 Armadillo-type fold
IPR016441 Uncharacterised conserved protein UCP005250
PFAM
PRINTS
PIRSF PIRSF005250
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91V83
PhosphoSite PhosphoSite-Q91V83
TrEMBL
UniProt Splice Variant
Entrez Gene 75425
UniGene Mm.487400
RefSeq XP_006500395
MGI ID
MGI Symbol Tti1
OMIM
CCDS CCDS16983
HPRD
IMGT
EMBL AF332067 AF332068 AK011692 AL663092 AL845511 BC053067 CH466551
GenPept AAH53067 AAK56095 AAK56096 BAB27782 CAM20389 CAM27321 EDL06248

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca