InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Klhl10

Summary

InnateDB Protein

IDBP-211416.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Klhl10

Protein Name

kelch-like 10 (Drosophila)

Synonyms

4921517C11Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001599

InnateDB Gene

IDBG-211414 (Klhl10)

Protein Structure

UniProt Annotation

Function

May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis. Required for male fertility. {ECO:0000269PubMed:15136734, ECO:0000269PubMed:16162871}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15136734}.

Disease Associations

Tissue Specificity

Testis specific. {ECO:0000269PubMed:15136734}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000902	cell morphogenesis
GO:0007286	spermatid development
GO:0008584	male gonad development
GO:0009566	fertilization
GO:0016567	protein ubiquitination
GO:0048808	male genitalia morphogenesis
GO:0048873	homeostasis of number of cells within a tissue

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:2181067

InterPro

IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011498 Kelch repeat type 2
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
IPR017096 Kelch-like protein, gigaxonin type

PFAM

PF01344
PF07646
PF07707
PF00651

PRINTS

PIRSF

PIRSF037037

SMART

SM00225
SM00612
SM00875

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt