Version 5.4
Mus musculus Protein: Ppp2r2d
Summary
InnateDB Protein IDBP-211451.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp2r2d
Protein Name protein phosphatase 2, regulatory subunit B, delta isoform
Synonyms 1300017E19Rik; D7Ertd753e; MDS026;
Species Mus musculus
Ensembl Protein ENSMUSP00000040321
InnateDB Gene IDBG-211449 (Ppp2r2d)
Protein Structure
UniProt Annotation
Function B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55- delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008601 protein phosphatase type 2A regulator activity
Biological Process
GO:0007067 mitotic nuclear division
GO:0007165 signal transduction
GO:0010458 exit from mitosis
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0000159 protein phosphatase type 2A complex
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1289252
InterPro IPR000009 Protein phosphatase 2A, regulatory subunit PR55
IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS PR00600
PIRSF PIRSF037309
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q925E7
PhosphoSite PhosphoSite-
TrEMBL G3UZP6
UniProt Splice Variant
Entrez Gene 52432
UniGene Mm.407323
RefSeq NP_080667
MGI ID
MGI Symbol Ppp2r2d
OMIM
CCDS CCDS21950
HPRD
IMGT
EMBL AC149221 AF366393 AK129386 BC066022 CH466531
GenPept AAH66022 AAK53703 BAC98196 EDL17838

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca