InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnajc7

Summary

InnateDB Protein

IDBP-211481.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnajc7

Protein Name

DnaJ (Hsp40) homolog, subfamily C, member 7

Synonyms

2010003F24Rik; 2010004G07Rik; CCRP; mDj11; mTpr2; Ttc2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000014339

InnateDB Gene

IDBG-211479 (Dnajc7)

Protein Structure

UniProt Annotation

Function

Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone- substrate complexes (By similarity). Recruits NR1I3 to the cytoplasm. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:14573755}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with NR1I3 at microtubules. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with high levels in liver, skeletal muscle, kidney and testis. {ECO:0000269PubMed:14573755}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031072	heat shock protein binding

Biological Process

GO:0070389

chaperone cofactor-dependent protein refolding

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1928373

InterPro

IPR001440 Tetratricopeptide TPR1
IPR001623 DnaJ domain
IPR013026 Tetratricopeptide repeat-containing domain
IPR013105 Tetratricopeptide TPR2
IPR019734 Tetratricopeptide repeat

PFAM

PF00515
PF00226
PF07719
PF13174
PF13176
PF13181

PRINTS

PR00625

PIRSF

SMART

SM00271
SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt