Version 5.4
Homo sapiens Protein: WBP11
Summary
InnateDB Protein IDBP-21159.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WBP11
Protein Name WW domain binding protein 11
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000261167
InnateDB Gene IDBG-21157 (WBP11)
Protein Structure
UniProt Annotation
Function Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. {ECO:0000269PubMed:10593949, ECO:0000269PubMed:11375989, ECO:0000269PubMed:14640981}.
Subcellular Localization Nucleus. Cytoplasm. Note=Predominantly located in the nucleus with granular heterogeneous distribution. Excluded from nucleoli in interphase cells, distributed throughout cytoplasm in dividing cells. Colocalized with SC35 and U2B in the nucleus. In the cytoplasm, associates with the intermediate filament protein vimentin.
Disease Associations
Tissue Specificity Ubiquitous. Highly expressed in the heart, pancreas, kidney skeletal muscle, placenta and brain (at protein level). Weakly expressed in liver and lung. {ECO:0000269PubMed:11375989}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 38 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0008599 protein phosphatase type 1 regulator activity
GO:0044822 poly(A) RNA binding
GO:0050699 WW domain binding
Biological Process
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR019007 WW domain binding protein 11
PFAM PF09429
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y2W2
PhosphoSite PhosphoSite-Q9Y2W2
TrEMBL F5GXS9
UniProt Splice Variant
Entrez Gene 51729
UniGene Hs.655138
RefSeq NP_057396
HUGO HGNC:16461
OMIM
CCDS CCDS8666
HPRD 18293
IMGT
EMBL AB029309 AC007655 AC010168 AF118023 AK297410 BC001621 BC016441 BC023532 CH471094
GenPept AAD30425 AAH01621 AAH16441 AAH23532 BAA88410 BAG59845 EAW96328 EAW96329

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca