InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stat3

Summary

InnateDB Protein

IDBP-211639.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stat3

Protein Name

signal transducer and activator of transcription 3

Synonyms

1110034C02Rik; Aprf; AW109958;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099403

InnateDB Gene

IDBG-211637 (Stat3)

Protein Structure

UniProt Annotation

Function

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. STAT3B interacts with the N-terminal part of JUN to activate such promoters in a cooperative way. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G. {ECO:0000269PubMed:11294897, ECO:0000269PubMed:23084476, ECO:0000269PubMed:23401489}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3 (By similarity). Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. {ECO:0000250}.

Disease Associations

Tissue Specificity

STAT3A is seen in the liver, spleen, and kidney. STAT3B is also detected in the liver, although in a much less abundant manner. Expressed in the lung and an increase in expression levels seen during methicillin-resistant S.aureus infection. {ECO:0000269PubMed:23401489}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 349 experimentally validated interaction(s) in this database.
They are also associated with 196 interaction(s) predicted by orthology.

Experimentally validated
Total	349 [view]
Protein-Protein	235 [view]
Protein-DNA	111 [view]
Protein-RNA	2 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	196 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0031730	CCR5 chemokine receptor binding
GO:0035259	glucocorticoid receptor binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0001659	temperature homeostasis
GO:0001754	eye photoreceptor cell differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006606	protein import into nucleus
GO:0006953	acute-phase response
GO:0007165	signal transduction
GO:0007259	JAK-STAT cascade
GO:0008283	cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0016310	phosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0019827	stem cell maintenance
GO:0019953	sexual reproduction
GO:0030522	intracellular receptor signaling pathway
GO:0032355	response to estradiol
GO:0040014	regulation of multicellular organism growth
GO:0042493	response to drug
GO:0042593	glucose homeostasis
GO:0042755	eating behavior
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0045747	positive regulation of Notch signaling pathway
GO:0045820	negative regulation of glycolytic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048708	astrocyte differentiation
GO:0060019	radial glial cell differentiation
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060548	negative regulation of cell death
GO:0070102	interleukin-6-mediated signaling pathway
GO:2001223	negative regulation of neuron migration

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:103038

InterPro

IPR000980 SH2 domain
IPR008967 p53-like transcription factor, DNA-binding
IPR013799 STAT transcription factor, protein interaction
IPR013800 STAT transcription factor, all-alpha
IPR013801 STAT transcription factor, DNA-binding
IPR015988 STAT transcription factor, coiled coil

PFAM

PF00017
PF14633
PF02865
PF01017
PF02864

PRINTS

PR00401

PIRSF

SMART

SM00252
SM00964

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt