InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Caly

Summary

InnateDB Protein

IDBP-211646.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Caly

Protein Name

calcyon neuron-specific vesicular protein

Synonyms

0710001P07Rik; 1110004A22Rik; Calcyon; Drd1ip;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026541

InnateDB Gene

IDBG-211644 (Caly)

Protein Structure

UniProt Annotation

Function

Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis. {ECO:0000250}.

Subcellular Localization

Cytoplasmic vesicle membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Most abundant in brain. Also expressed in testis and ovary and, at much lower levels, in kidney and heart. {ECO:0000269PubMed:12853145}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0032051	clathrin light chain binding
GO:0032403	protein complex binding

Biological Process

GO:0006897	endocytosis
GO:0007212	dopamine receptor signaling pathway
GO:0045807	positive regulation of endocytosis
GO:0048268	clathrin coat assembly

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0031410	cytoplasmic vesicle