InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fuom

Summary

InnateDB Protein

IDBP-211659.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fuom

Protein Name

RIKEN cDNA 1810014F10 gene

Synonyms

Fucu; Le51;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026539

InnateDB Gene

IDBG-211657 (Fuom)

Protein Structure

UniProt Annotation

Function

Involved in the interconversion between alpha- and beta- L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O- glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes. {ECO:0000269PubMed:17602138}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed in various tissues and cell lines, including kidney, liver, and pancreas, marginally in muscle and testis. {ECO:0000269PubMed:17602138}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016853	isomerase activity
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives
GO:0042806	fucose binding
GO:0048029	monosaccharide binding

Biological Process

GO:0005996	monosaccharide metabolic process
GO:0006004	fucose metabolic process
GO:0036065	fucosylation
GO:0045665	negative regulation of neuron differentiation
GO:0060180	female mating behavior