InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mtg1

Summary

InnateDB Protein

IDBP-211685.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mtg1

Protein Name

mitochondrial GTPase 1 homolog (S. cerevisiae)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036491

InnateDB Gene

IDBG-211683 (Mtg1)

Protein Structure

UniProt Annotation

Function

Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0015093	ferrous iron transmembrane transporter activity

Biological Process

GO:0006184	GTP catabolic process
GO:0015684	ferrous iron transport
GO:0042254	ribosome biogenesis
GO:0044065	regulation of respiratory system process
GO:0070129	regulation of mitochondrial translation

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0005761	mitochondrial ribosome
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2685015

InterPro

IPR006073 GTP binding domain
IPR011619 Ferrous iron transport protein B, N-terminal
IPR016478 GTPase, MTG1
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01926
PF02421

PRINTS

PR00326

PIRSF

PIRSF006230

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt