InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sprn

Summary

InnateDB Protein

IDBP-211688.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sprn

Protein Name

shadow of prion protein

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053901

InnateDB Gene

IDBG-211686 (Sprn)

Protein Structure

UniProt Annotation

Function

Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP. {ECO:0000269PubMed:17703189}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:17703189}; Lipid-anchor, GPI-anchor {ECO:0000269PubMed:17703189}.

Disease Associations

Tissue Specificity

Mainly expressed in brain (at protein level). In brain, it is highly expressed in the hippocampus and cerebellum and is also expressed at lower level in other areas of the brain including the cerebral cortex, the thalamus and the medulla. In hippocampus and cerebellum it is highly expressed in the cell bodies of pyramidal cells and Purkinje cells, respectively. {ECO:0000269PubMed:17703189}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding

Biological Process

GO:0006606

protein import into nucleus

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031225	anchored component of membrane
GO:0031982	vesicle