InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TMPRSS11D

Summary

InnateDB Protein

IDBP-21170.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMPRSS11D

Protein Name

transmembrane protease, serine 11D

Synonyms

HAT;

Species

Homo sapiens

Ensembl Protein

ENSP00000283916

InnateDB Gene

IDBG-21168 (TMPRSS11D)

Protein Structure

UniProt Annotation

Function

May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. {ECO:0000269PubMed:23536651, ECO:0000269PubMed:24227843}.

Subcellular Localization

Cell membrane; Single-pass type II membrane protein. Note=Activated by cleavage and secreted.Transmembrane protease serine 11D catalytic chain: Secreted. Note=Activated by cleavage and secreted.

Disease Associations

Tissue Specificity

Located in the cells of the submucosal serous glands of the bronchi and trachea.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0008233	peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0007585	respiratory gaseous exchange

Cellular Component

GO:0005576	extracellular region
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000082 SEA domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR015420 Peptidase S1A, nudel
IPR017329 Peptidase S1A, HAT/DESC1

PFAM

PF01390
PF00089
PF09342

PRINTS

PR00722

PIRSF

PIRSF037941

SMART

SM00200
SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References