Mus musculus Protein: Coasy | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-211818.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | Coasy | ||||||||||
Protein Name | Coenzyme A synthase | ||||||||||
Synonyms | 1300003G02Rik; Dpck; Ppat; Ukr1; | ||||||||||
Species | Mus musculus | ||||||||||
Ensembl Protein | ENSMUSP00000001806 | ||||||||||
InnateDB Gene | IDBG-211816 (Coasy) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. | ||||||||||
Subcellular Localization | Cytoplasm {ECO:0000250}. Mitochondrion matrix {ECO:0000250}. Note=The protein is mainly present in the mitochondrial matrix, probably anchored to the inner mitochondrial membrane, but this protein is also present in cell lysate. {ECO:0000250}. | ||||||||||
Disease Associations | |||||||||||
Tissue Specificity | Widely expressed with highest levels in kidney and lowest levels in colon, lung, intestine, and spleen. {ECO:0000269PubMed:11980892}. | ||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | MGI:1918993 | ||||||||||
InterPro |
IPR001977
Dephospho-CoA kinase IPR004821 Cytidyltransferase-like domain IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF01121
PF01467 |
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PRINTS | |||||||||||
PIRSF | |||||||||||
SMART | |||||||||||
TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | Q9DBL7 | ||||||||||
PhosphoSite | PhosphoSite-Q9DBL7 | ||||||||||
TrEMBL | |||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 71743 | ||||||||||
UniGene | Mm.182271 | ||||||||||
RefSeq | XP_006534318 | ||||||||||
MGI ID | 2F6R | ||||||||||
MGI Symbol | Coasy | ||||||||||
OMIM | |||||||||||
CCDS | CCDS25446 | ||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | AF521095 AK004878 AK159405 AK159912 AK166894 BC020046 BX255926 | ||||||||||
GenPept | AAH20046 AAM77669 BAB23636 BAE35057 BAE35475 BAE39099 CAM24464 | ||||||||||