Version 5.4
Mus musculus Protein: Syce1
Summary
InnateDB Protein IDBP-211830.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Syce1
Protein Name synaptonemal complex central element protein 1
Synonyms 4933406J07Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000026553
InnateDB Gene IDBG-211828 (Syce1)
Protein Structure
UniProt Annotation
Function Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination. {ECO:0000269PubMed:15944401}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15944401}. Chromosome {ECO:0000269PubMed:15944401}. Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE2 in the central elements.
Disease Associations
Tissue Specificity Meiotic cells (at protein level). Expressed in the ovary and testis. {ECO:0000269PubMed:15944401}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007130 synaptonemal complex assembly
Cellular Component
GO:0000795 synaptonemal complex
GO:0000801 central element
GO:0005654 nucleoplasm
Protein Structure and Domains
PDB ID MGI:1921325
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D495
PhosphoSite PhosphoSite-Q9D495
TrEMBL
UniProt Splice Variant
Entrez Gene 74075
UniGene Mm.46102
RefSeq NP_001137237
MGI ID
MGI Symbol Syce1
OMIM
CCDS CCDS52436
HPRD
IMGT
EMBL AK016694
GenPept BAB30383

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca