InnateDB Protein
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IDBP-21193.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MLLT1
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Protein Name
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myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
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Synonyms
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ENL; LTG19; YEATS1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000252674
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InnateDB Gene
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IDBG-21191 (MLLT1)
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Protein Structure
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Function |
Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. {ECO:0000269PubMed:20159561, ECO:0000269PubMed:20471948}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
Note=A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation t(11;19)(q23;p13.3) with KMT2A/MLL1. The result is a rogue activator protein.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
36
[view]
|
Protein-Protein |
36
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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|
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Molecular Function |
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Biological Process |
GO:0006355
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regulation of transcription, DNA-templated
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0006469
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negative regulation of protein kinase activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR005033
YEATS
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PFAM |
PF03366
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q03111
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PhosphoSite |
PhosphoSite-Q03111
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
4298
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UniGene |
|
RefSeq |
NP_005925
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HUGO |
HGNC:7134
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OMIM |
159556
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CCDS |
CCDS12160
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HPRD |
15933
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IMGT |
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EMBL |
D14539
L04285
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GenPept |
AAA58457
BAA03406
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