InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ifitm2

Summary

InnateDB Protein

IDBP-211936.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ifitm2

Protein Name

interferon induced transmembrane protein 2

Synonyms

DSPA2c; fragilis3; Ifitm3l; mil-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000071470

InnateDB Gene

IDBG-211934 (Ifitm2)

Protein Structure

UniProt Annotation

Function

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV) and West Nile virus (WNV). Can inhibit: influenza virus hemagglutinin protein- mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53- independent manner. {ECO:0000269PubMed:21253575}.

Subcellular Localization

Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Predominantly expressed in nascent primordial germ cells, as well as in gonadal germ cells. {ECO:0000269PubMed:12659663}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0009607	response to biotic stimulus
GO:0009615	response to virus
GO:0045087	innate immune response
GO:0046597	negative regulation of viral entry into host cell
GO:0051607	defense response to virus