InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: B4galnt4

Summary

InnateDB Protein

IDBP-211961.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

B4galnt4

Protein Name

beta-1,4-N-acetyl-galactosaminyl transferase 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000039758

InnateDB Gene

IDBG-211959 (B4galnt4)

Protein Structure

UniProt Annotation

Function

Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. {ECO:0000250}.

Subcellular Localization

Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008376	acetylgalactosaminyltransferase activity
GO:0016758	transferase activity, transferring hexosyl groups
GO:0033842	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity

Biological Process

GO:0008152

metabolic process

Cellular Component

GO:0016021	integral component of membrane
GO:0032580	Golgi cisterna membrane

Protein Structure and Domains

PDB ID

MGI:2652891

InterPro

IPR001173 Glycosyltransferase 2-like
IPR008428 Chondroitin N-acetylgalactosaminyltransferase
IPR011658 PA14
IPR029044 Nucleotide-diphospho-sugar transferases

PFAM

PF00535
PF05679
PF07691

PRINTS

PIRSF

SMART

SM00758

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q766D5