InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ada

Summary

InnateDB Protein

IDBP-211964.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ada

Protein Name

adenosine deaminase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000017841

InnateDB Gene

IDBG-211962 (Ada)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte- epithelial cell adhesion (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Cell junction {ECO:0000250}. Cytoplasmic vesicle lumen {ECO:0000269PubMed:8783262}. Cytoplasm {ECO:0000250}. Note=Colocalized with DPP4 at the cell junction in lymphocyte- epithelial cell adhesion. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in brain neurons in the median emninence (at protein level). Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time of weaning, in gastrointestinal tissues. {ECO:0000269PubMed:8783262}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001883	purine nucleoside binding
GO:0004000	adenosine deaminase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019239	deaminase activity

Biological Process

GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0001821	histamine secretion
GO:0001829	trophectodermal cell differentiation
GO:0001889	liver development
GO:0001890	placenta development
GO:0002314	germinal center B cell differentiation
GO:0002636	positive regulation of germinal center formation
GO:0002686	negative regulation of leukocyte migration
GO:0002906	negative regulation of mature B cell apoptotic process
GO:0006154	adenosine catabolic process
GO:0006157	deoxyadenosine catabolic process
GO:0007155	cell adhesion
GO:0007568	aging
GO:0009168	purine ribonucleoside monophosphate biosynthetic process
GO:0010460	positive regulation of heart rate
GO:0030324	lung development
GO:0030890	positive regulation of B cell proliferation
GO:0032261	purine nucleotide salvage
GO:0033089	positive regulation of T cell differentiation in thymus
GO:0033197	response to vitamin E
GO:0033632	regulation of cell-cell adhesion mediated by integrin
GO:0042110	T cell activation
GO:0042323	negative regulation of circadian sleep/wake cycle, non-REM sleep
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0043066	negative regulation of apoptotic process
GO:0043103	hypoxanthine salvage
GO:0043278	response to morphine
GO:0045187	regulation of circadian sleep/wake cycle, sleep
GO:0045580	regulation of T cell differentiation
GO:0045582	positive regulation of T cell differentiation
GO:0045987	positive regulation of smooth muscle contraction
GO:0046061	dATP catabolic process
GO:0046101	hypoxanthine biosynthetic process
GO:0046103	inosine biosynthetic process
GO:0046111	xanthine biosynthetic process
GO:0046638	positive regulation of alpha-beta T cell differentiation
GO:0048286	lung alveolus development
GO:0048541	Peyer's patch development
GO:0048566	embryonic digestive tract development
GO:0050728	negative regulation of inflammatory response
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050862	positive regulation of T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation
GO:0060169	negative regulation of adenosine receptor signaling pathway
GO:0060407	negative regulation of penile erection
GO:0070244	negative regulation of thymocyte apoptotic process
GO:0070256	negative regulation of mucus secretion

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0030054	cell junction
GO:0032839	dendrite cytoplasm
GO:0043025	neuronal cell body
GO:0060205	cytoplasmic membrane-bounded vesicle lumen