InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ywhab

Summary

InnateDB Protein

IDBP-211993.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ywhab

Protein Name

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

Synonyms

1300003C17Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000018470

InnateDB Gene

IDBG-211991 (Ywhab)

Protein Structure

UniProt Annotation

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Melanosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 215 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	42 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	215 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0032403	protein complex binding
GO:0042826	histone deacetylase binding
GO:0050815	phosphoserine binding
GO:0051219	phosphoprotein binding

Biological Process

GO:0006605	protein targeting
GO:0035308	negative regulation of protein dephosphorylation
GO:0043085	positive regulation of catalytic activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051220	cytoplasmic sequestering of protein
GO:0051291	protein heterooligomerization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0017053	transcriptional repressor complex
GO:0030659	cytoplasmic vesicle membrane
GO:0042470	melanosome
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome