InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tomm34

Summary

InnateDB Protein

IDBP-212015.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tomm34

Protein Name

translocase of outer mitochondrial membrane 34

Synonyms

2610100K07Rik; TOM34;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000018466

InnateDB Gene

IDBG-212013 (Tomm34)

Protein Structure

UniProt Annotation

Function

Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1 is ubiquitously expressed while isoform 2 is expressed only in mature testicular germ cells. Isoform 1 is expressed in all testicular cells. Isoform 2 is highly expressed in early to late pachytene cells but expression is significantly decreased in round spermatid cells. {ECO:0000269PubMed:12801914}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031072	heat shock protein binding

Biological Process

GO:0006626

protein targeting to mitochondrion

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1914395

InterPro

IPR001440 Tetratricopeptide TPR1
IPR013026 Tetratricopeptide repeat-containing domain
IPR013105 Tetratricopeptide TPR2
IPR019734 Tetratricopeptide repeat

PFAM

PF00515
PF07719
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CYG7