Version 5.4
Mus musculus Protein: Rassf7
Summary
InnateDB Protein IDBP-212069.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rassf7
Protein Name Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
Synonyms 2400009B11Rik; AW210608;
Species Mus musculus
Ensembl Protein ENSMUSP00000038444
InnateDB Gene IDBG-212067 (Rassf7)
Protein Structure
UniProt Annotation
Function Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti- apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Colocalizes with gamma-tubulin. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
Protein Structure and Domains
PDB ID MGI:1914235
InterPro IPR000159 Ras-association
IPR029071 Ubiquitin-related domain
PFAM PF00788
PRINTS
PIRSF
SMART SM00314
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9DD19
PhosphoSite PhosphoSite-
TrEMBL D3Z133
UniProt Splice Variant
Entrez Gene 66985
UniGene Mm.21202
RefSeq NP_080162
MGI ID
MGI Symbol Rassf7
OMIM
CCDS CCDS40182
HPRD
IMGT
EMBL AC108908 AK002243 BC011131
GenPept AAH11131 BAB21960

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca