InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Irf7

Summary

InnateDB Protein

IDBP-212083.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irf7

Protein Name

interferon regulatory factor 7

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026571

InnateDB Gene

IDBG-212081 (Irf7)

Protein Structure

UniProt Annotation

Function

Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages. {ECO:0000269PubMed:15361868, ECO:0000269PubMed:15743772, ECO:0000269PubMed:15800576, ECO:0000269PubMed:18562536}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15361868}. Cytoplasm {ECO:0000269PubMed:15361868}. Note=The phosphorylated and active form accumulates selectively in the nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	21 [view]
Protein-DNA	12 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	59 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0002819	regulation of adaptive immune response
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0016064	immunoglobulin mediated immune response
GO:0032607	interferon-alpha production
GO:0032608	interferon-beta production
GO:0032727	positive regulation of interferon-alpha production
GO:0032728	positive regulation of interferon-beta production
GO:0034124	regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0034127	regulation of MyD88-independent toll-like receptor signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045088	regulation of innate immune response
GO:0045351	type I interferon biosynthetic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060340	positive regulation of type I interferon-mediated signaling pathway