Version 5.4
Mus musculus Protein: Irf7
Summary
InnateDB Protein IDBP-212085.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Irf7
Protein Name interferon regulatory factor 7
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000095565
InnateDB Gene IDBG-212081 (Irf7)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 59 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 21 [view]
Protein-DNA 12 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 59 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000975 regulatory region DNA binding
GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0016064 immunoglobulin mediated immune response
GO:0045087 innate immune response (InnateDB)
GO:0045351 type I interferon biosynthetic process
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
Cellular Component
Protein Structure and Domains
PDB ID MGI:1859212
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
IPR008984 SMAD/FHA domain
IPR019471 Interferon regulatory factor-3
PFAM PF00605
PF10401
PRINTS PR00267
PIRSF
SMART SM00348
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q3TW14
UniProt Splice Variant
Entrez Gene 54123
UniGene
RefSeq NP_001239529
MGI ID
MGI Symbol Irf7
OMIM
CCDS CCDS57595
HPRD
IMGT
EMBL AC163434 AK152403 AK159883 CH466531
GenPept BAE31191 BAE35453 EDL18025

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca