InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aoc3

Summary

InnateDB Protein

IDBP-212097.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aoc3

Protein Name

amine oxidase, copper containing 3

Synonyms

SSAO; VAP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099394

InnateDB Gene

IDBG-212089 (Aoc3)

Protein Structure

UniProt Annotation

Function

Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin- independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005261	cation channel activity
GO:0005507	copper ion binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008131	primary amine oxidase activity
GO:0046982	protein heterodimerization activity
GO:0048038	quinone binding
GO:0052593	tryptamine:oxygen oxidoreductase (deaminating) activity
GO:0052594	aminoacetone:oxygen oxidoreductase(deaminating) activity
GO:0052595	aliphatic-amine oxidase activity
GO:0052596	phenethylamine:oxygen oxidoreductase (deaminating) activity

Biological Process

GO:0006812	cation transport
GO:0007155	cell adhesion
GO:0009308	amine metabolic process
GO:0046677	response to antibiotic
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0009986	cell surface
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1306797

InterPro

IPR000269 Copper amine oxidase
IPR015798 Copper amine oxidase, C-terminal
IPR015800 Copper amine oxidase, N2-terminal
IPR015802 Copper amine oxidase, N3-terminal
IPR016182 Copper amine oxidase, N-terminal

PFAM

PF01179
PF02727
PF02728

PRINTS

PR00766

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O70423