InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: G6pc

Summary

InnateDB Protein

IDBP-212099.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

G6pc

Protein Name

glucose-6-phosphatase, catalytic

Synonyms

AW107337; G6Pase; G6pt; Glc-6-Pase;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019469

InnateDB Gene

IDBG-267049 (G6pc)

Protein Structure

UniProt Annotation

Function

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. {ECO:0000269PubMed:8640227}.

Subcellular Localization

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004346	glucose-6-phosphatase activity
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0042301	phosphate ion binding

Biological Process

GO:0005977	glycogen metabolic process
GO:0005980	glycogen catabolic process
GO:0006094	gluconeogenesis
GO:0006641	triglyceride metabolic process
GO:0006796	phosphate-containing compound metabolic process
GO:0008202	steroid metabolic process
GO:0010468	regulation of gene expression
GO:0015760	glucose-6-phosphate transport
GO:0016311	dephosphorylation
GO:0032094	response to food
GO:0035264	multicellular organism growth
GO:0042593	glucose homeostasis
GO:0042632	cholesterol homeostasis
GO:0046415	urate metabolic process
GO:0046838	phosphorylated carbohydrate dephosphorylation
GO:0051156	glucose 6-phosphate metabolic process
GO:0055088	lipid homeostasis

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle