InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Drd4

Summary

InnateDB Protein

IDBP-212127.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Drd4

Protein Name

dopamine receptor D4

Synonyms

AW125663; D4R; Drd-4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026569

InnateDB Gene

IDBG-212125 (Drd4)

Protein Structure

UniProt Annotation

Function

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells. {ECO:0000269PubMed:24048828}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0004930	G-protein coupled receptor activity
GO:0004952	dopamine receptor activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0017124	SH3 domain binding
GO:0035240	dopamine binding
GO:0042802	identical protein binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001662	behavioral fear response
GO:0001963	synaptic transmission, dopaminergic
GO:0001975	response to amphetamine
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212	dopamine receptor signaling pathway
GO:0007614	short-term memory
GO:0007623	circadian rhythm
GO:0008306	associative learning
GO:0008344	adult locomotory behavior
GO:0008355	olfactory learning
GO:0009648	photoperiodism
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0032417	positive regulation of sodium:proton antiporter activity
GO:0033674	positive regulation of kinase activity
GO:0034776	response to histamine
GO:0042053	regulation of dopamine metabolic process
GO:0042596	fear response
GO:0042752	regulation of circadian rhythm
GO:0046928	regulation of neurotransmitter secretion
GO:0048148	behavioral response to cocaine
GO:0048545	response to steroid hormone
GO:0050482	arachidonic acid secretion
GO:0050709	negative regulation of protein secretion
GO:0050804	regulation of synaptic transmission
GO:0050848	regulation of calcium-mediated signaling
GO:0060041	retina development in camera-type eye
GO:0060080	regulation of inhibitory postsynaptic membrane potential
GO:0060406	positive regulation of penile erection
GO:1901386	negative regulation of voltage-gated calcium channel activity
GO:2000463	positive regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005938	cell cortex
GO:0012506	vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043197	dendritic spine
GO:0043679	axon terminus

Protein Structure and Domains

PDB ID

MGI:94926

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000929 Dopamine receptor family
IPR002185 Dopamine D4 receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00242
PR00569

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P51436