InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aarsd1

Summary

InnateDB Protein

IDBP-212143.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aarsd1

Protein Name

alanyl-tRNA synthetase domain containing 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000067912

InnateDB Gene

IDBG-212152 (Aarsd1)

Protein Structure

UniProt Annotation

Function

Functions in trans to edit the amino acid moiety from incorrectly charged Ser-tRNA(Ala). {ECO:0000269PubMed:18172502}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0002161	aminoacyl-tRNA editing activity
GO:0002196	Ser-tRNA(Ala) hydrolase activity
GO:0003676	nucleic acid binding
GO:0004813	alanine-tRNA ligase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016876	ligase activity, forming aminoacyl-tRNA and related compounds
GO:0046872	metal ion binding

Biological Process

GO:0006419	alanyl-tRNA aminoacylation
GO:0006450	regulation of translational fidelity
GO:0043039	tRNA aminoacylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1916934

InterPro

IPR012947 Threonyl/alanyl tRNA synthetase, SAD
IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain
IPR018164 Alanyl-tRNA synthetase, class IIc, N-terminal
IPR018165 Alanyl-tRNA synthetase, class IIc, core domain

PFAM

PF07973
PF01411

PRINTS

PIRSF

SMART

SM00863

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3THG9