InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sdc4

Summary

InnateDB Protein

IDBP-212146.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sdc4

Protein Name

syndecan 4

Synonyms

AA959608; AW108331; ryudocan; Synd4; syndecan-4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000017153

InnateDB Gene

IDBG-212144 (Sdc4)

Protein Structure

UniProt Annotation

Function

Cell surface proteoglycan that bears heparan sulfate.

Subcellular Localization

Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form.

Disease Associations

Tissue Specificity

Ubiquitous. Highest levels in liver, kidney and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0070053	thrombospondin receptor activity

Biological Process

GO:0001657	ureteric bud development
GO:0007165	signal transduction
GO:0045087	innate immune response (InnateDB)
GO:0045860	positive regulation of protein kinase activity
GO:0051496	positive regulation of stress fiber assembly
GO:0051894	positive regulation of focal adhesion assembly

Cellular Component

GO:0005576	extracellular region
GO:0005796	Golgi lumen
GO:0005925	focal adhesion
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0043034	costamere
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome