InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eps8l2

Summary

InnateDB Protein

IDBP-212163.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eps8l2

Protein Name

EPS8-like 2

Synonyms

AI042819; AW545405; Eps8r2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026577

InnateDB Gene

IDBG-212161 (Eps8l2)

Protein Structure

UniProt Annotation

Function

Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in fetal kidney, adrenal gland, salivary gland, stomach, gut, cartilage and skin. Detected in adult ovary, placenta, skin, adrenal gland, salivary gland, kidney, intestine and stomach. {ECO:0000269PubMed:14565974}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0051015	actin filament binding

Biological Process

GO:0007266	Rho protein signal transduction
GO:0016601	Rac protein signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:1900029	positive regulation of ruffle assembly

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0032587	ruffle membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:2138828

InterPro

IPR001452 SH3 domain
IPR006020 PTB/PI domain
IPR011511 Variant SH3 domain
IPR013625 Tensin phosphotyrosine-binding domain
IPR013761 Sterile alpha motif/pointed domain

PFAM

PF00018
PF14604
PF00640
PF14719
PF07653
PF08416

PRINTS

PR00452

PIRSF

SMART

SM00326
SM00462

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt