Version 5.4
| Mus musculus Protein: Eppin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||
| InnateDB Protein | IDBP-212248.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Eppin | ||||||||
| Protein Name | serine protease inhibitor-like, with Kunitz and WAP domains 1 (eppin) | ||||||||
| Synonyms | 1700024E17Rik; Spinlw1; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000099389 | ||||||||
| InnateDB Gene | IDBG-212246 (Eppin) | ||||||||
| Protein Structure |
|
||||||||
| UniProt Annotation | |||||||||
| Function | Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Secreted. Cell surface. Note=Present on the surface of spermatozoa both before and after capacitation. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Expressed in differentiated spermatogonia in testis. Expressed in spermatogonia cell lines GC-1 spg and GC- 2spd(ts) as well as in the Leydig tumor cell line MLTC-1 (at protein level). Expressed specifically in epididymis and testis. Expressed predominantly on the postacrosomal region of mouse spermatozoa, in Sertoli cells, Leydig cells, and round spermatids in the testis, and in the principal cells of the cauda epididymidis epithelium. {ECO:0000269PubMed:12909348, ECO:0000269PubMed:21461566}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
||||||||
| Gene Ontology | |||||||||
Molecular Function |
|
||||||||
| Biological Process |
|
||||||||
| Cellular Component |
|
||||||||
| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1922776 | ||||||||
| InterPro |
IPR002223
Proteinase inhibitor I2, Kunitz metazoa IPR008197 Whey acidic protein-type 4-disulphide core |
||||||||
| PFAM |
PF00014
PF00095 |
||||||||
| PRINTS |
PR00759
PR00003 |
||||||||
| PIRSF | |||||||||
| SMART |
SM00131
SM00217 |
||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9DA01 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 75526 | ||||||||
| UniGene | |||||||||
| RefSeq | NP_083601 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Eppin | ||||||||
| OMIM | |||||||||
| CCDS | CCDS17043 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF346413 AK006296 AL591478 BC048637 CH466551 | ||||||||
| GenPept | AAH48637 AAK31335 BAB24514 CAM15019 EDL06403 | ||||||||